The Fundamental Triad in Dental Medicine
Building up the “Suitability Relationship”
BioCellgraft Inc., as the premier global biotech company in oral health must pay and receive tribute from numerous innovation actors in different manners.
This disruptive company represents:
- The fruit of innovation out of a much larger field of research and clinical development on placenta pioneered and led currently by Dr. R. Hariri and its organization Cellularity Inc. (New Jersey, USA).
- The trigger of innovation in oral surgery and dentistry for the upcoming years by demonstrating its vitality and the strong presence of its regenerative solutions portfolio globally.
- The catalysator of collaborations and networks conveying the ambition and success of the “thinking out of the box” in regenerative dental medicine.
As a DDS trained during the last century in surgery, I must write that our education as surgeons does not prone us to become a “thinker out of the box”. In the contrary we remain conservative and protective to avoid any troubles with our employer, health administration, peers and patients. This leads to what I call a distortion in the “suitability relationship”.
The “suitability relationship” in regenerative dental medicine corresponds to a system of three elementary structures where the patient, the material and the operator are supposed to interact harmoniously forming a fundamental triad.
The patient is clearly defined with respect to diagnosis and prognosis. This variable cannot be changed.
The material if suitable fits to the clinical needs of the patient. This variable results from an educated decision of the operator which could or could not become questionable.
The operator should undoubtfully demonstrate the required skills to conduct the surgical procedure. He/she represents the most adaptable variable in the system but the weakest one too because of our general lack of curiosity and courage.
As surgeons we tend to reproduce the same procedures whatever material we are using. We think scarcely “out of the box” staying in what we believe being our comfort zone but in fact that can become a material misuse.
Because we simply refuse to adapt our technique to the material, we open the Pandora box! Shame on us!
At BioCellgraft Inc. we consider that the material supplier must adapt to this situation and contribute decisively by providing a device/regenerative solution which:
- Is chemically and biologically pure with fully identified and identifiable components even during the degradation or resorption process if it will happen. This shall guaranty the safety and the biocompatibility but will not warranty the performance itself.
Our Human Placenta Connective Tissue Matrix (HPCTM, brand name OraFyl™) is fully decellularized respecting the macro-molecular structures composition and interactions between collagen and elastin.
- Due to its immunological neutrality, integrates into and assimilate with the host soft tissue because of their close similarity in structure and composition. At the same time, it remains mechanically stable because the collagen-elastin interactions which allow for elasticity (like a spiral spring) exhibit controlled degradation/resorption properties on demand through a fully controlled process after implantation into a living organism.
In the case of OraFyl™, due to its fully preserved elasticity, the product behaves a couple of weeks and before the full assimilation will be completed like a young native collagen matrix providing a naturally controlled mechanical stress which has a positive effect on cells metabolism and tissue regeneration. The implantation of HPCTM does not induce any mechanical function disruption.
- Presents with a long shelf life (about 10 years) without requiring any special conditions of temperatures (room temperature), humidity or light for storage and reconstitution.
- Is versatile, this allowing for tailoring the final material into an injectable or implantable form depending on amount of added saline and/or tissue substitute concentration, and to different surgical techniques fitting each application mode (insertion or injection) and related clinical indication.
- Is usable to take advantage of obvious and easy logistics and storage and preparation conditions in the operation theatre, self-explaining in reconstitution for surgical use with no long training necessary.
Allowing for dual or plural applications: injectable, mixable or topical to cover as many clinical situations as possible with only one type of material (HPCTM).
The main requirement for BioCellgraft’s HPCTM OraFyl™ is to be injected into the thickness of the gingiva without flap elevation or gently mixed with a bone or soft tissue substitute material in case of bony implantation or gingival placement.
BioCellgraft’s HPCTM OraFyl™ can be used as a stand-alone gel (soft tissue enhancement) or as an adjuvant mixed with bone/soft connective tissue graft of any origin (autograft, allograft, xenograft) to prepare a graft with enhanced biological and handling properties.
All together the above advantages allow for an educated use, encompassing several treatment options. This almost intuitive easy use should limit the time and resources invested in T&E efforts.
BioCellgraft bears on its shoulders the responsibility to deliver a truly innovative regenerative solutions such as OraFyl™ and OraFyl-M™, which offers all possible aspects for success in real-life use in regenerative dental medicine as follows:
high biochemical purity, biological and functional integration, versatility, usability, logistics and storage friendly.
It’s up to you my colleagues and fellows, to properly identify the patient and the indication as to propose the most suitable and adapted surgical procedure with courage and determination.
Thinking out of the box has nothing to do with craziness, it has to do with serving better our patient by giving him/her access to a true personalized precision dental medicine approach.
Building up the “suitability relationship” is a mindset not a simple recipe, it helps to institutionalize the fundamental triad in dental medicine.
